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Reproduction studies have been performed in rats at doses up to 10 times the human dose and have revealed no evidence of impaired fertility and no teratological findings. Sulbactam and cefoperazone cross the placental barrier. There are; however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Zifam CS1/CS2 should be used during pregnancy only if clearly needed.
Only small quantities of sulbactam and cefoperazone are excreted in human milk. Although both drugs pass poorly into breast milk of nursing mothers, caution should be exercised when Zifam CS1/CS2 is administered to a nursing mother.
